Recent Article Published: Shape directed biomineralization of gold nanoparticles using self-assembled lipid structures

Rukan Genc*, Gael Clergeaud, Mayreli Ortiz and Ciara O’Sullivan*

Biomater. Sci., 2014, Advance Article DOI: 10.1039/C4BM00025K, Paper 

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As one of the building blocks of the cell membrane, lipids and their interaction with neighboring lipids and other molecules, as well as their ability to form different kinds of structures, have garnered immense interest. By exploiting the effective shape and thermal-phase behavior of lipids, we have prepared lipid superstructures such as twisted ribbons and rectangular and hexagonal shaped lipidic nanostructures using the curvature tuned preparation method. These lipidic superstructures were then used as nanoreactor templates for the inorganic synthesis of diversely shaped and sized gold nanostructures exploring different administration routes of reducing agents, citrate, and tetrachloroauric acid, which as a result formed different organizations of gold nanoparticles aligned and guided by the template structure. Tailor-designed metallic nanostructures can be obtained through a careful selection of lipids and conditions for lipid superstructure preparation and their consequent use as template nanoreactors. The diversely sized and shaped gold nanostructures obtained have great potential for catalysis and plasmonics.

Book Chapter Published in “Biosensors: Recent advances and mathematical challenges”

Book Chapter Published in “Biosensors: Recent advances and mathematical challenges”

About the Book: Many researchers and research groups around the globe are dealing with interdisciplinary problems and multidisciplinary groups; but especially those that deal everyday with biosensors have the feeling of not having enough personnel with the sufficient background to cover all topics. With this feeling in our minds, we decided to invite wonderful researchers from different parts to design this book, not as a conventional biosensor’s book, but as an interesting journey in the complex world of biosensors. A close look to some recent and key advances on the topic, but at the same time tips through novel mathematical modelling to improve our work, and last but not least, tricks to fool those undesired electrical  disturbances that commonly messes our daily work can be found in these pages.

Feel free to navigate the book through its chapters, once in your hands you will feel eager to learn more about biosensors. It has been an experience to put all this together; but now, with the book ready, we can say that this trip has being a wonderful adventure. That is why want to thank all the authors for their great contributions, the Editorial and Irene for their constant input, and to you, the reader, for being part of this book.

About the Chapter (1)-Use of functonal metalic nanostructures in biosensors by Rükan Genç. 

The number of diferent type of nanostructures is increasing and wide range of nanoscale materials of diferent sizes, shapes and compositons are now available . From those, mainly, nanomaterials can be divided into three main classes depending on the material they are made up of: i) inorganic nanopartcles where the core material is an inorganic element or mixture (e.g; gold, silver, TiO2, ZnO, CdS and so on), ii) organic sof nanomaterials which are formed of organic materials including lipids, peptdes, genetc material, and finally, iii) nanocomposites which are based on both organic and inorganic materials, for example, magnetosomes, metal coated carbon nanotubes  and peptde amphiphiles. However, this chapter will only cover the state of the art associated to the advantages ofered by diferent types of inorganic nanomaterials and their composites. Collecton of literature on challenges and drawbacks, and real world applicatons of these kinds of nanomaterials in biosensor development, including current status and future prospects will also be served to the readers’ interest.

Top 10 most-read Faraday Discussions articles – Q4 2013

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Cell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of anticancer drugs to tumor cells

Melis Sardan, Murat Kilinc, Rukan Genc, Ayse B. Tekinay and Mustafa O. Guler

 Faraday Discuss., 2013,166, 269-283 DOI: 10.1039/C3FD00058C, Paper

Article published in Faraday Discussions  during the PostDoc stage of Dr. Rükan Genç in Biomimetics Lab (BML) of UNAM is listed as the top 10 most readed article from October-December of 2013.  Manuscript covers development of  a cell penetrating peptite amphiphile integrated liposomal system  which  further has been conducted to in vitro tests to demonstrate their delivery potential as anticancer drug carrier. “Curvature Tuned Liposome Preparation” methodology developed by Rükan Genç during her Ph.D was used to prepare liposomes which were functionalized by peptite amphiphiles designed in BML.