Recent Article Published: Aluminum doped carbon nanodots as potent adjuvants on the mammalian macrophages

In this manuscript, we aimed to report the synthesis of aluminum (Al) incorporated carbon nanodots (CD) and their activities on the immune cells. A green synthesis method involving the in-situ doping of the nanodot was conducted. Synthesized nanodots immunomodulatory and immunostimulatory activities were tested invitro on the macrophages. The produced
carbon dots were water-soluble, fluorescent and monodispersed, with an average diameter of around 10–20nm. After Al-doping, their surface properties, stability, crystallinity, as well as their fluorescent and optical properties were evaluated.
These Al-CDs displayed no cytotoxicity and enhanced the pro-inflammatory activities of the mammalian macrophages witmuch lower aluminum concentrations (‰ 20) compared to that of conventional aluminum salt, by virtue of which they havthe potential to serve as the safe and effective adjuvant carrier. The stability of the nanocarriers was found to be persistent for over 3 months at room temperature with no significant formation of the aggregates. These results support the promise of such nanodots as the new generation non-toxic adjuvant candidates
Cite This Article: Ayaz, F et al. (2019)  Molecular Biology Reports

Recent Article Published: One-pot synthesis of hydrophilic and hydrophobic fluorescent carbon dots using deep eutectic solvents as designer reaction media

Carbon dots are often synthesized in the presence of a carbon source and passivating agents in which they are crucial for an enhanced fluorescence. The solvent choice and/or combination to be used in the synthesis of these nanoparticles can influence their surface chemical composition, morphology, and fluorescence properties. In this study, highly fluorescent carbon dots were synthesized using deep eutectic solvents of different compositions as green solvent media and doping agent. Resulting carbon dots were then separated by their hydrophilicity/hydrophobicity using a three-phase solvent system (water/acetone/chloroform) and compared with traditional centrifugation-based separation method. Carbon dots with a size below 20 nm and quantum yield reaching 50% were obtained. Many properties of them including surface functional groups, optical, fluorescence, and electric properties were shown to be determined by the deep eutectic solvent composition.


Journal of Materials Science 53(4) (2018) DOI: 10.1007/s10853-018-2723-4

Recent Article Published: High-Capacitance Hybrid Supercapacitor Based on Multi-Colored Fluorescent Carbon-Dots

tocfiguresonMulti-colored, water soluble fluorescent carbon nanodots (C-Dots) with quantum yield
changing from 4.6 to 18.3% were synthesized in multi-gram using dated cola beverage
through a simple thermal synthesis method and implemented as conductive and ion
donating supercapacitor component. Various properties of C-Dots, including size, crystal
structure, morphology and surface properties along with their Raman and electron
paramagnetic resonance spectra were analyzed and compared by means of their
fluorescence and electronic properties. α-Manganese Oxide-Polypyrrole (PPy) nanorods
decorated with C-Dots were further conducted as anode materials in a supercapacitor.
Reduced graphene oxide was used as cathode along with the dicationic bis-imidazolium
based ionic liquid in order to enhance the charge transfer and wetting capacity of …


Scientific Reportsvolume 7, Article number: 11222 (2017)

Recent Article Published: An investigation into the role of macromolecules of different polarity as passivating agent on the physical, chemical and structural properties of fluorescent carbon nanodots

In this study, comparative evaluation of fluorescent carbon nanodots (C-Dots) prepared using carob molasses was reported by screening various biocompatible macromolecules as passivating agent (PA). Incorporation of PAs with different molecular weight, polarity, and chemical structure was examined, and compared with the polyethylene glycol (PEG, Mn = 10 kN) passivated and pristine C-Dots. Not only the fluorescence properties but also many other features including size, crystal structure, colloidal conductivity, resistance to photobleaching, quantum yield, and UV-modulated surface interaction of them with the reactive oxygen species (ROS) as well as ROS production were investigated. Photoluminescence (PL) capacity of C-Dots was found to be associated with the number of surface alkyl groups and polymeric hydrogen bonding present on the C-Dot surface (increased number is associated with decreased PL) while the surface conductivity of C-Dots in water was proportional to the PL intensity. More importantly, C-Dots with relatively poorer fluorescent were investigated in various organic solvents (hexane, methanol, acetone, ethanol, dimethylformamide (DMF), and DMSO). As happens with the fluorescent dyes, their PL intensities were significantly enhanced (even for pristine C-Dots) depending on the solvent characteristics. All of the C-Dots synthesized were further evaluated by means of UV-induced generation of ROS and inhibition of ROS by using H2O2 as a model. In contrary to other carbonaceous nanomaterials, they did not show any ROS generation, on the contrary, they showed ROS scavenging activity that can be modulated by UV-irradiation (λexc = 365 nm). PEG and alginate passivated C-Dots inhibited H2O2 activity at LC50 values below 10 mg/mL.



Cite this article as: Alas, M.O. & Genc, R. J Nanopart Res (2017) 19: 185. doi:10.1007/s11051-017-3863-1

Recent Article Published: Green Synthesis of Fluorescent Carbon Nanoparticles and Investigation of the Effect of Passivating Agent Molecular Weight on Nanoparticle Properties

In this research article , synthesis of fluorescent carbon nanoparticles from a natural carbon source, carob molasses, was investigated. To this end, thermal synthesis methodology as a green synthesis method with the easşekil2iness to carry out Black Hat Seo and being economical was followed and polyethylene glycol of different molecular weight (PEG Mn: 300~20000) was used as surface passivating agent.  Synthesized fluorescent carbon nanoparticles (FCNPs) were then characterized by field emission scanning electron microscope (FE-SEM), transmission electron microsocope (TEM), X-Ray Diffraction Analysis (XRD), UV spectrophotometer, fluorescence spectrophotometer, dynamic light scattering (DLS) methods. Results showed that surface properties of nanoparticles and fluorescent properties as a result were found to be determined by the molecular weight of the passivation agent. Moreover, hydrodynamic size of nanoparticles with core diameter measured as 10-15 nm was also found to be increased with increased polymer Mn.

MÖ Alas, R Genc  (2016) Sinop Üniversitesi Fen Bilimleri Dergisi 1 (2), 123-129

Recent Book Chapter Published: Nanoparticle based sensor platforms for facile detection of food contaminants (Chapter 10) in Nanobiosensors (Academic Press, Elseiver)

A Grumezescu

Academic Press



     As a comprehensive resource on nanotechnology in the agri-food industry, this book presents the principles and safety applications of biosensor nanotechnology.


2209A TUBITAK Undergrad Research Project Fellowship

IMG-20150507-WA0019Our undergrad student Zeynep Meray was awarded to TUBITAK 2209-AResearch Projects Support Program for Undergraduate Students with her graduate project entitled in “Photosystem I-magnetic nanoparticle composites for solar cell applications: Synthesis and Characterization”. We congratulate her for the efforts and wish her a successful  academic life. 

Cicada wing nanostructure able to kill bacteria on contact

( —A combined team of researchers from Spain and Australia has discovered what they claim is the first known instance of a biomaterial that can kill bacteria on contact based only its physical surface structure. In their paper published in Biophysical Journal, the team describes how they found that clanger cicadas have nanoscale sized pillars on their wings that trap and slowly kill bacteria by pulling their cells apart.

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