Recent Article Published: Magnetic nanoparticle-loaded electrospun poly(ε-caprolactone) nanofibers for drug delivery applications

Sunu1In this study, iron oxide (Fe 3 O 4) magnetic nanoparticles (MNPs) were loaded into poly (ε-
caprolactone)(PCL) nanofıber mats via electrospinning method and the composite materials
were characterized. MNPs were synthesized by a conventional co-precipitation method and
treated by oleic acid to obtain hydrophobic nanoparticles. The MNPs were added to PCL
solution before electrospinning at varying MNP feed concentrations (1: 25, 2: 25, 4: 25, 8: 25,
16: 25 and 32: 25; weight ratio of MNPs: polymer). The chemical structure of the nanofibrous
membranes was investigated by Fourier transform infrared spectroscopy (FTIR). Scanning
electron microscopy (SEM), and analyses by optical and confocal microscopes
demonstrated that MNP-loaded PCL nanofibers (MNP@ PCL NFs) were homogeneously
distributed in the membranes. Fiber diameter changed and bead formation occurred as …


Cite this article as:Demir, D., Güreş, D., Tecim, T. et al. Appl Nanosci (2018).

Recent article published: Magnetic nanoparticle embedded stimuli responsive hydrogels as anti-inflammatory drug-carriers

Sibel Barbaros, Rukan Genç*

Dokuz Eylul Universitesi Muhendislik Dergisi, 18(1) pp31-3., 2016, DOI:10.21205/deufmd.20165217543.

In this study, magnetic alginate beads were successfully synthesized by integrating superparamagnetic iron oxide nanoparticles (Fe3O4) in sodium alginate microbeads during the synthesis. The as-obtained dried samples were analyzed by means of their water detention capacity and drug encapsulation efficiency. Further, an anti-inflammatory drug (Cefazolin), mostly used for the treatment of joint inflammations after surgery, was used as a model drug in order to evaluate the stimuli-responsive properties of macrocomposites under magnetic field for the development of on-site drug delivery system. To do so, their drug release kinetics at changing environmental conditions, such as pH, temperature, and magnetic field were investigated and compared with bare alginate beads.