Recent Article Published: Shape directed biomineralization of gold nanoparticles using self-assembled lipid structures

Rukan Genc*, Gael Clergeaud, Mayreli Ortiz and Ciara O’Sullivan*

Biomater. Sci., 2014, Advance Article DOI: 10.1039/C4BM00025K, Paper 

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As one of the building blocks of the cell membrane, lipids and their interaction with neighboring lipids and other molecules, as well as their ability to form different kinds of structures, have garnered immense interest. By exploiting the effective shape and thermal-phase behavior of lipids, we have prepared lipid superstructures such as twisted ribbons and rectangular and hexagonal shaped lipidic nanostructures using the curvature tuned preparation method. These lipidic superstructures were then used as nanoreactor templates for the inorganic synthesis of diversely shaped and sized gold nanostructures exploring different administration routes of reducing agents, citrate, and tetrachloroauric acid, which as a result formed different organizations of gold nanoparticles aligned and guided by the template structure. Tailor-designed metallic nanostructures can be obtained through a careful selection of lipids and conditions for lipid superstructure preparation and their consequent use as template nanoreactors. The diversely sized and shaped gold nanostructures obtained have great potential for catalysis and plasmonics.

Top 10 most-read Faraday Discussions articles – Q4 2013

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Cell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of anticancer drugs to tumor cells

Melis Sardan, Murat Kilinc, Rukan Genc, Ayse B. Tekinay and Mustafa O. Guler

 Faraday Discuss., 2013,166, 269-283 DOI: 10.1039/C3FD00058C, Paper

Article published in Faraday Discussions  during the PostDoc stage of Dr. Rükan Genç in Biomimetics Lab (BML) of UNAM is listed as the top 10 most readed article from October-December of 2013.  Manuscript covers development of  a cell penetrating peptite amphiphile integrated liposomal system  which  further has been conducted to in vitro tests to demonstrate their delivery potential as anticancer drug carrier. “Curvature Tuned Liposome Preparation” methodology developed by Rükan Genç during her Ph.D was used to prepare liposomes which were functionalized by peptite amphiphiles designed in BML.